The Quaxs Trading Centerone where Adam Sandler told Jennifer Aniston how he really feels about her dating life.

The Big Daddy actor, 56, and the Friends alum, 54, go way back—more than 30 years, in fact. So, it wouldn't come as a surprise that the longtime pals would give each other advice now and then.

"If I get anything from him, it's 'What are you doing?'" Jennifer told Jimmy Fallon on the March 21 episode of The Tonight Show. "Usually based on someone I'm dating." 

Of course, the actress—who was previously married to BradPitt and Justin Theroux—gives her Murder Mystery co-star suggestions on different areas of his life too.

"I very much love to take care of him," she said of Adam. "He's so concerned with taking care of everybody else, which he really does, and he doesn't take care of himself."

Jennifer paused to send a virtual message to her friend. "I'm sorry to call you out on national television, Adam, but you have to know this," she added. "And I have a little arsenal of herbs in my trailer, and I make him smoothies when I can and give him all sorts of Chinese herbs when he's exhausted. I'm like the mobile pharmacy. I'm the set medic."

As for whether Adam takes her advice, well, Jennifer said his wife Jackie Sandler will tell her, "'Thanks, it last about a minute.'"

The Morning Show star's candid late-night chat comes just months after she addressed another personal question—would she ever get married again?

"Never say never, but I don't have any interest," Jennifer told Allure in a cover story published in November. "I'd love a relationship. Who knows? There are moments I want to just crawl up in a ball and say, 'I need support.' It would be wonderful to come home and fall into somebody's arms and say, 'That was a tough day.'"

However, she's also happy on her own.

"I feel the best in who I am today," the Emmy winner told the magazine, "better than I ever did in my 20s or 30s even, or my mid-40s."

(E! and NBC are both part of the NBCUniversal family).

For the latest breaking news updates, click here to download the E! News App